Researchers have revealed the mechanisms by which cells enter senescence because of an imbalance in the number of chromosomes. Chromosomal instability is a common trait in most solid tumors, such as ...

Chromosomal instability plays a crucial role in the progression of cancer: it shapes the properties of tumor cells and drives the development of therapy resistance. Scientists used state-of-the-art ...

This study introduces TEAM (Targeted Elimination and Microcell-Mediated Transfer), a novel programmable platform that enables ...

Osaka, Japan - Gross chromosomal rearrangements—where portions of the genome become moved, deleted, or inverted—can lead to cell death and diseases such as cancer in complex multicellular organisms.

Triple negative breast cancer (TNBC) is one of the most aggressive and hardest forms of breast cancer to treat, but a new study led by Weill Cornell Medicine suggests a surprising way to stop it from ...

Plasma proteome-based integrative prognostic nomogram in metastatic castrate-resistant prostate cancer (mCRPC). Transcriptional profiling of patients with metastatic hormone-sensitive prostate cancer ...

Utilizing commercial health insurance claims data to identify the impact of cancer screening and estimate the added benefit of a multicancer liquid biopsy ordered during routine physical exams.

With age comes an increased risk of many infections. The mechanisms connecting aging and weakened immunity, however, have remained unclear. A new study has identified a category of genetic markers in ...

Sex chromosome abnormalities, including missing or extra X and Y chromosomes, can be difficult to detect in ancient DNA as it slowly erodes over time or becomes contaminated. Scientists have now ...

Separate studies led by scientists at Dartmouth Hitchcock Medical Center (DMHC) and Queens University offer some clarity about the hidden causes of recurrent pregnancy loss. Data from both studies is ...