Natural products derived from plants, fungi, and even microbes have been fruitful sources of drugs. Now research shows that their chemical mirror images may be an underexplored source of potential ...

It is well established that an enantiomerically pure compound exhibiting advantageous properties not present in its isomer or its corresponding racemic mixture, can be patented even if its ...

New biocatalytic and chemocatalytic routes to chiral intermediates and developments in simulated-moving-bed and supercritical-fluid chromatography for resolving racemic mixtures. The prevalence of ...

A C&EN article describes efforts to create artificial saliva to treat xerostomia, which radiation treatment for head and neck cancers can cause (Dec. 11/18, 2023, page 17). Cancer.net estimates nearly ...

(A) Binding energies of (-)-morphine and (+)-morphine interacting with MOR. (B) Binding pocket residues of (-)-morphine and (+)-morphine in MOR, visualized from the extracellular side. (C) W293 ...

From 2001 to 2011, the US Food and Drug Administration approved 9 single-enantiomer drugs with racemic precursors. None showed pre-approval evidence of improved efficacy over the racemic precursor. We ...

Single-enantiomer drugs account for nearly 40% of the global pharmaceutical market. The author analyzes the current market for single-enantiomer drugs, their role as a generic drug defense strategy, ...

Researchers have developed a technology to create a hybrid catalyst from simple-structured, commercially available rhodium and organic catalysts, which reduces chemical waste and produces molecules ...

Stereochemistry relates to the spatial organization of atoms in a molecule. Often molecules having the same chemical makeup can exist in different spatial arrangements. These related molecules are ...