Platelet factor 4 - Wikipedia
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of …
Platelet factor 4(PF4) and its multiple roles in diseases
Mar 1, 2024 · Herein, we discussed the characteristics and biological functions of PF4, summarized PF4-mediated signaling pathways, and discussed its role in different diseases to inform novel …
Antibodies against Platelet Factor 4 and Their Associated Pathologies ...
Platelet factor 4 (PF4) is a 70-amino acid protein that is stored in alpha granules of platelets and is released on platelet activation [1]. PF4 is cationic, or positively charged, and forms tetramers at …
Thrombotic anti-PF4 immune disorders: HIT, VITT, and beyond
Dec 8, 2023 · Antibodies against the chemokine platelet factor 4 (PF4) occur often, but only those that activate platelets induce severe prothrombotic disorders with associated thrombocytopenia.
PF4 Gene - GeneCards | PLF4 Protein | PLF4 Antibody
Jan 15, 2026 · PF4 (Platelet Factor 4) is a Protein Coding gene. Diseases associated with PF4 include Heparin-Induced Thrombocytopenia and Erythromelalgia. Among its related pathways are MIF …
What Is Platelet Factor 4 (PF4) and What Does It Do?
Jul 28, 2025 · PF4 is positively charged and forms tetramers, or groups of four protein units, under normal physiological conditions. PF4 plays a role in moderating blood coagulation. Its primary …
PF4 - Platelet factor 4 - Homo sapiens (Human) - UniProt
Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis …
Molecular architecture and platelet-activating properties of small ...
Mar 11, 2024 · Platelet factor 4 (PF4) is a chemokine that is secreted from activated platelets 1 and involved in a variety of physiological processes, ranging from coagulation and tissue repair to innate...
PF4 platelet factor 4 [Homo sapiens (human)] - Gene - NCBI
Nov 19, 2025 · Gene target information for PF4 - platelet factor 4 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
Platelet factor 4 regulates hematopoietic stem cell aging
Dec 4, 2025 · Here, we show that the age-related alterations of the megakaryocytic niche and associated downregulation of platelet factor 4 (PF4) are pivotal mechanisms driving HSC aging.