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Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying development and disease, but the considerable variation between lines makes it challenging to replicate findings across research groups. New in Cell Press Stem Cell, JAX's Skarnes lab and others deeply characterized eight iPSC lines and found that "KOLF2.1J" was an all-around, well-performing line with high genomic stability after gene editing. This cell line can now act as a stable foundation for modeling hundreds
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