BOOMERANG 🪃 SIGN It's a boomerang 🪃-shaped region of cytotoxic edema in the splenium of the corpus callosum typically seen in cytotoxic lesions of the corpus callosum (CLOCC) CLOCCs are seen in patients with seizures or metabolic disturbances, although many other etiologies are recognized. Reported etiologies include: seizures complex relationship – CLOCCs seen in a variety of settings: A. antiseizure medications (with or without seizures) B. sudden cessation of antiseizure medications (classi